Here are a few suggestions for accommodation:
Best Western Premier C – Hamilton Mountain - nicest hotel by far and in a good area that gets you to Toronto quickly from the hwy. It is a 20 minute drive to the wedding venue and you can easily order cabs to pick you up.
Super 8 - Grimsby – very close 5 minute drive to the wedding venue, very cheap and right on the QEW highway that takes you to Niagara Falls as well as Toronto. If you mention the De Luca- Onyemere wedding you will get a discounted rate.
Casablanca Winery Inn – Grimsby - very close 5 minute drive to wedding venue (next door to Super 8) http://casablancawineryinn.com/
B&B – Winona – Built in the 1850s the house is conveniently located 80 km west of Toronto just off of the QEW and right at the start of Niagara's 20 km wine route on the outskirts of Grimsby and roughly 30 min drive from the U.S. border - flowery and quaint and in a pretty Canadian home http://webhome.idirect.com/~pebbles/
B&B – Beamer Falls – 3 minute drive to wedding venue (or 10 minute walk) Really lovely od farm house with ensuite rooms and a nice outdoor space. http://beamerfalls.ca/index.php?pr=Home_Page
Holiday Inn Express – Stoney Creek – 10 minutes to wedding venue and very close to hwy to get to Toronto and Niagara Falls. Cheap and easy to get cabs. http://www.ihg.com/holidayinnexpress/hotels/gb/en/hamilton/yhmex/hoteldetail